The pain between the big toe and the second toe can be caused by the following reasons: first, toe neuritis, toe neuritis is due to chronic inflammation of the toe nerve between the toes, resulting in pain in the middle of the big toe and the second toe, which should be investigated and examined at an early stage and treated with nerve nutrition and physical therapy at an early stage. Secondly, toe neuroma, when the toe nerve has a neurological tumor, there can also be neuropathic pain between the big toe and the second toe, which should be investigated early, diagnosed early, treated early with oral medication and, if necessary, surgical treatment. Third, metatarsophalangeal headitis, metatarsophalangeal headitis patients can also have pain between the big toe and the second toe at the metatarsal head, the pain is more obvious when walking long distances or straining, then we should check the foot X-ray, CT and physical examination for diagnosis and early treatment.