When the patient has a large gap between high pressure and low pressure, i.e. the difference between systolic pressure and diastolic pressure is large, also known as a large pulse pressure difference, which is usually greater than 60mmHg, it may be triggered because of atherosclerosis, aortic valve closure insufficiency, hyperthyroidism, severe anemia and other reasons. 1. Atherosclerosis: In general, if the patient’s symptoms are more serious, the high pressure may be very high while the low pressure may be very low, and the difference between the high pressure and the low pressure will be bigger. 2. Aortic valve insufficiency: In this case, there is blood reflux in the diastolic portion of the aorta, which causes diastolic blood pressure to fall and systolic blood pressure to rise, resulting in a large gap between high and low blood pressure. 3. Hyperthyroidism: Hyperthyroidism will cause the body to secrete a large amount of thyroid hormones, which will lead to an increase in blood pressure, thus causing a large gap between high and low pressure. In addition, severe anemia can also cause the pulse pressure difference to increase. It is recommended that patients go to the hospital for a systematic examination and clarify the cause of the disease, and can take amlodipine, nifedipine controlled-release tablets and other antihypertensive drugs under the guidance of the doctor to control the condition, but follow the doctor’s instructions, do not blindly use their own drugs.