Whether the endometrial uneven thickness adhesion is serious or not depends on the severity of the adhesion, the patient’s physical condition, etc. It cannot be generalized, and the patient should follow the doctor’s instructions for standardized treatment. Uneven endometrial thickness adhesion is usually caused by uterine surgery, abortion, diagnostic scraping, infectious operation, etc., which leads to endometrial damage, causing uneven thickness of the endometrium and resulting in adhesion, which is mainly manifested by menstrual changes, abdominal pain, infertility and other symptoms. If the degree of adhesion is mild, the endometrium can be separated through hysteroscopic surgery, and estrogen and other drugs can be used to stimulate the regeneration of the endometrium and restore the reproductive function, and the prognosis is generally good. If the endometrial adhesions are more severe, the condition is usually more serious and prone to recurrence, making it difficult to restore normal fertility through treatment. Patients with endometrial adhesions of uneven thickness should be detected, diagnosed and treated early to improve the prognosis and pregnancy rate.