Uric acid 404 μmol/L in a 65 year old female is considered high. The normal reference range for uric acid in a normal adult female is 89 to 357 μmol/L. Therefore, a uric acid of 404 μmol/L in a 65-year-old female is high, and the cause needs to be identified and intervened. Elevated uric acid may be a manifestation of damage to glomerular filtration, primary gout due to hereditary enzyme deficiencies, or an abnormal increase in uric acid production in the body due to hematological disorders or malignancies. It can also be seen in the long-term use of diuretics and anti-tuberculosis drugs, or in people who have been fasting for a long time, or in people with chronic lead poisoning. Patients are advised to take dietary adjustments, such as avoiding high purine foods such as animal offal, seafood, etc., abstaining from alcohol and reducing weight, drinking a lot of water, drinking more than 2,000 ml of water per day, and urinating regularly. Therefore, it is recommended that 65-year-old women with elevated uric acid should consult a rheumatologist in a timely manner to identify the cause of the disease and carry out targeted treatment under the guidance of the doctor.