The treatment modes for advanced lung cancer with multiple metastases include chemotherapy, radiotherapy, targeted therapy and general treatment. 1. Chemotherapy: if the patient’s general condition is still good and he/she can tolerate the adverse effects of chemotherapy drugs, he/she can choose appropriate chemotherapy program according to the pathological type of tumor. For example, cyclophosphamide, paclitaxel, pemetrexed and so on. 2. Radiotherapy: according to the specific location of the patient’s lesion, local radiotherapy can be chosen, such as localized bone metastasis, brain metastasis radiotherapy, and so on. 3. Targeted therapy: Lung adenocarcinoma patients can be tested by gene test, and EGFR-positive patients can choose Gefitinib and Erlotinib; ALK-positive patients can choose Crizotinib and Ceritinib for oral administration. 4. Immunotherapy: At present, immunotherapy mainly consists of PD-1/PD-L1 inhibitors, patients can choose immunotherapy under the guidance of doctors according to the results of PD-1/PD-L1 gene test. 5. General treatment: patients with advanced lung cancer are recommended to strengthen nutrition, have regular checkups, correct electrolyte disorders, infections and other complications. For advanced lung cancer with multiple metastases, it is recommended to consult with oncology specialists, choose appropriate treatment plan after completing relevant examinations, correct the patient’s general condition, and actively treat the disease to improve clinical symptoms, enhance the quality of life and prolong the survival period. Please strictly follow the doctor’s prescription for drug treatment and do not use drugs by yourself.