Patients with SLE can gradually stabilize their disease after standardized treatment, and their medication can be gradually reduced. However, because of various factors (such as cold, infection, pregnancy, surgery, exertion, mental shock, sunlight exposure, discontinuation of medication, etc.), the disease may recur, and some people may change from stable to active stage. So when should we consider a change in the disease, i.e. a relapse? We can judge from clinical symptoms and laboratory tests. If you encounter the following cases, you should consider disease review and seek medical attention in a timely manner: 1. Fever of unknown origin: that is, fever that cannot be explained by the common cold, respiratory tract infection, urinary tract infection, gastrointestinal tract infection or other causes; 2. New rash, especially vasculitis-like rash at the ends of the fingers (toes); 3. New ulcer foci in the mouth and nose; 4. Hair loss; 5. Recurrent joint swelling and pain; 6. pleural effusion or pericardial effusion that cannot be explained by other causes; 7. swelling and increased proteinuria; 8. leukocytopenia or thrombocytopenia or increased anemia; 9. neurological symptoms such as dizziness, headache, vomiting, convulsions, etc.; 10. increased titers of ANA (anti-nuclear antibody) and anti-double-stranded DNA antibody; 11. increased blood sedimentation; 12. decreased complement, especially C3. We ask patients to return to the hospital regularly for follow-up and blood check, in order to detect changes in the disease at an early stage, make timely judgment of disease recurrence, adjust the medication and avoid delaying the disease. Complement and ANA and anti-double-stranded DNA antibodies are common laboratory indicators for judging the activity of SLE, but one should not be sure that it is lupus relapse as long as one sees abnormal test results; one needs to analyze comprehensively whether there are other reasons to avoid miscalculation, which may skew the direction of treatment or even cause major accidents. Therefore, we would like to remind everyone to seek medical attention promptly after the appearance of the above-mentioned symptoms, and early and reasonable treatment will enable the patients to obtain a good prognosis.