Prednisone, methylprednisolone and prednisone have similar side effects, but according to the dosage of the drug, the specific condition and personal situation and other differences, the patient whether the side effects and the degree of side effects there are greater differences, can not be judged directly which side effects are greater. Methylprednisolone and prednisone are commonly used glucocorticosteroid drugs, both have anti-inflammatory, anti-allergic, immunosuppressive effects, drug indications and side effects are similar, long-term use of methylprednisolone and prednisone treatment may be side effects include osteoporosis, gastrointestinal tract ulcers, water and sodium retention, intracranial pressure increased, intraocular pressure increased, etc. Almost all of the drugs can cause side effects, but according to the dosage and individual differences, whether or not the patient has a greater degree of side effects can not be directly judged. Almost all drugs can cause side effects, but there are differences in the incidence and extent of side effects. Some patients may not experience side effects after taking the drugs, while some patients may experience life-threatening side effects after taking the drugs, and the incidence and extent of side effects are related to the dosage of the drugs administered, personal circumstances and other factors. Methylprednisolone and prednisone should be used under the guidance of a physician, and it is recommended that patients go to the relevant departments of regular hospitals for detailed consultation.