Chronic non-atrophic gastritis with bile reflux can be treated with medications such as gastric mucosal protectants, gastrointestinal stimulants, acid inhibitors, etc. or surgical procedures such as gastrojejunostomy Roux-en-Y and Henley jejunal collateral replacement.
1. Pharmacological treatment:
(1) Gastric mucosal protective agent: commonly used drugs are aluminum thioglycollate can protect gastric mucosa, magnesium aluminum carbonate can also adsorb bile refluxed into the stomach, which can form a layer of protection on the surface of the gastric mucosa to avoid the damage of bile to the gastric mucosa and promote the repair of the gastric mucosa.
(2) Gastrointestinal stimulants: commonly used drugs include domperidone, mosapride, etc., which can promote gastrointestinal peristalsis, reduce reflux and the retention time of bile and pancreatic juice in the stomach.
(3) Acid inhibitors: commonly used drugs such as omeprazole and pantoprazole can inhibit the secretion of gastric acid and reduce the damage of digestive juices to gastric mucosa.
2.Surgical treatment:
(1) Gastrojejunostomy Roux-en-Y: after surgery, food can flow directly into the jejunum from the stomach, and bile flows to the distal end of the gastrojejunal anastomosis via the duodenum to avoid bile flow through the gastric anastomosis, thus preventing bile reflux into the stomach.
(2) Henley jejunal collaterals replacement: after the operation, food can be mixed with bile in the duodenal passage first, thus reducing bile reflux.
If chronic non-atrophic gastritis with bile reflux is diagnosed, early and standardized treatment is recommended to minimize the adverse effects of the disease. All of the above medications should be used under doctor’s supervision, avoid self-medication.