Soreness in four or five lumbar vertebrae may be caused by cold, aseptic inflammation due to long-term strain, and lumbar disc herniation. Treatment mainly includes lifestyle improvement, physical therapy and medication. 1. Cold and aseptic inflammation: patients who suffer from pain due to cold need to pay attention to lumbar warmth and avoid long-term exposure of the lumbar region; patients who suffer from aseptic inflammation due to long-term stooping labor are advised to take rest, braking, and wearing a waist cuff for protection; heat therapy, massage, and red light can also be chosen to increase lumbar blood circulation, promote the discharge of acidic metabolites, and alleviate muscle fatigue and tension. 2. Lumbar disc herniation: patients with obvious pain symptoms and lumbar disc herniation can take oral celecoxib, indomethacin and other painkillers; patients with lumbar disc herniation compression of nerves can also take methylcobalamin, vitamin B12 and other nutritive peripheral nerves; intravenous mannitol, dexamethasone and other drugs to reduce edema. The above drugs need to be used under the guidance of a doctor, avoid self-medication. If the patient’s symptoms are severe, or if the symptoms continue without improvement, the patient should go to the hospital in time for treatment.