The most common adverse reactions to Nimesulide granules are gastrointestinal reactions such as burning, nausea, and stomach pain. In rare cases, patients develop an allergic rash after taking the drug. In addition, it may lead to hepatic and renal impairment and gastric bleeding, so it should be contraindicated in people with gastrointestinal ulcers, severe hepatic and renal insufficiency, and those who are allergic to Nimesulide. Even if the above side effects do not occur with Nimesulide, it should be noted that this product, like other NSAIDs, may cause dizziness, drowsiness, gastric ulcer or gastrointestinal bleeding, and Stevens-Johnson syndrome. The risk of adverse reactions, particularly gastrointestinal bleeding and perforation, is increased in elderly patients with NSAIDs and may be fatal. Adverse reactions can be minimized by using the lowest effective dose for the shortest duration of treatment, depending on the need for symptom control. Serious liver injury from this product has been reported rarely, and lethality has been reported even more rarely. Patients who develop symptoms of liver injury (e.g., anorexia, nausea, vomiting, abdominal pain, fatigue, red urine) during treatment with this product and patients with abnormal liver function tests should be discontinued and should not continue to take this product. Patients are advised to avoid the concomitant use of analgesic drugs and the combination of other NSAIDs is not recommended. There is a risk that patients may develop gastrointestinal bleeding or ulcer perforation, and treatment with this product should be discontinued if gastrointestinal bleeding or ulceration occurs. Because this product can affect platelet function, it should be used with caution in patients with a tendency to bleed. However, it should not be used as a substitute for acetylsalicylic acid in the prevention of cardiovascular events. This product may impair fertility in women and is therefore not recommended for use in women who are preparing to conceive.