Leg itching in renal insufficiency is mainly caused by increased toxin level, calcium and phosphorus metabolism disorder or dry skin. Renal insufficiency can lead to a variety of metabolites such as blood creatinine, urea nitrogen and a variety of toxins, which can not be normally excreted from the body, so that they accumulate in the skin, thus causing itchy skin symptoms of the lower limbs. Calcium and phosphorus metabolism disorders, secondary hyperparathyroidism, β2 microglobulin deposition, etc., can lead to itchy skin of the lower extremities. Skin moisture deficiency, skin sweat gland reduction, etc. can lead to itchy legs, can follow the doctor’s instructions to apply glycerine lotion, emollient lotion, gabapentin and other treatments, at the same time need to strengthen the hemodialysis toxin removal, or combined with hemodiafiltration, hemoperfusion, etc. to remove large molecules of toxins, to achieve the effect of stopping the itch. Patients with renal insufficiency itchy legs, it is recommended to go to the regular hospital in time for diagnosis and treatment, avoid blind medication to avoid delaying the condition.