Urine protein 2+ is generally not serious. However, whether it is serious or not needs to be analyzed according to different causes. Pathological factors such as urinary tract infection, glomerulonephritis and other causes, generally more serious, need to address the cause of the disease, to take targeted treatment; physiological conditions, such as strenuous exercise, eating a lot of high-protein food, etc., generally not serious, pay attention to rest, light diet can be improved. 1.Pathological factors (1) Urinary tract infection: Because when patients have pyelonephritis caused by urinary tract infection, it will lead to the reduction of renal function, so that the absorption rate of protein molecules by the kidney decreases, leading to the symptoms of proteinuria, which in turn will make the urine routine examination show the manifestation of urinary protein 2+. It is usually more serious and requires anti-infection treatment as prescribed by the doctor, such as amoxicillin and cefixime. (2) Glomerulonephritis: Glomerulonephritis may lead to urinary protein 2+, because glomerulonephritis causes abnormal glomerular filtration function, leading to more protein leakage, which increases the protein molecules in the urine, leading to urinary protein 2+ in urine test. Generally more serious, if necessary, need to follow the doctor’s advice to improve the nephropuncture, clear pathology type, give prednisone acetate or cyclosporine treatment. 2. Physiological factors such as strenuous exercise, eating a lot of high-protein foods, nutcracker syndrome, etc., there can be urine protein 2 +, at this time is not serious, strengthen the rest, light diet, weight gain, generally can be returned to normal. It is recommended that patients with urinary protein 2+ go to the nephrology department of the regular hospital in time, under the guidance of the doctor for testing, clear cause of the disease and early treatment.