The most dangerous period for monochorionic monoamniotic twins is 16-28 weeks of gestation. Monochorionic monoamniotic twins are a relatively rare form of twins in which the two fetuses share a placenta and an amniotic sac, and there is no amniotic sac separating the two fetuses, creating a variety of different positions such as two fetuses facing each other. Monochorionic monoamniotic twin pregnancy occurs at a higher risk than other twins, more likely to lead to a variety of complications, in addition to the twin transfusion syndrome, but also may lead to the umbilical cord knots, umbilical cord torsion, umbilical cord entanglement neck, and other serious harm to the growth and development of the fetus. In order to avoid the risk of monochorionic monoamniotic twins, it is best to wait until the 37th week of pregnancy to deliver as soon as possible, monochorionic monoamniotic twins to follow the doctor’s instructions to the hospital regularly to carry out obstetric examinations, in order to avoid the occurrence of adverse reactions.