Ibuprofen tablets, piroxicam and dexamethasone are not recommended to be taken together. Ibuprofen tablets and piroxicam are non-steroidal anti-inflammatory drugs (NSAIDs), and dexamethasone belongs to the class of glucocorticoid drugs. The precautions in the description of piroxicam tablets have already stated that the drug should be avoided to be used in combination with other non-steroidal anti-inflammatory drugs such as ibuprofen and aspirin. The other three drugs are used together to increase the risk of gastrointestinal bleeding and other risks, so ibuprofen tablets, piroxicam, dexamethasone three drugs are not recommended to take together. Common adverse drug reactions to ibuprofen tablets, piroxicam broadly include nausea, vomiting, dyspepsia, etc. The use of these two drugs is not recommended for patients who are allergic to the ingredients of ibuprofen tablets, piroxicam tablets, patients with active peptic ulcers, and women during pregnancy and lactation. Dexamethasone common adverse drug reactions include infection, diabetes, peptic ulcer, etc. The presence of electrolyte abnormalities, myocardial infarction, psychosis, glaucoma and other contraindications to the use of this drug is not recommended for patients. Drugs need to be used under the guidance of a physician, it is recommended to take ibuprofen tablets, piroxicam, dexamethasone three kinds of drugs to the regular hospital department for detailed consultation, do not take the drug on their own.