Gastric mesenchymal tumor is a mesenchymal tumor originating from the intrinsic muscular layer or mucosal layer of the gastric wall and is the most common non-epithelial tumor of the gastrointestinal tract. Gastric mesenchymal tumors have insidious symptoms and are difficult to diagnose at an early stage. Gastrointestinal mesenchymal tumor is characterized by non-directional differentiation and potential malignancy, and surgical resection is the best treatment for gastrointestinal mesenchymal tumor. How extensive resection can no longer improve the efficacy, laparoscopic surgery is currently one of the main surgical procedures for gastric mesenchymal tumor surgery because of its small trauma, short operation time and short hospital stay. Factors affecting the prognosis besides whether it can be completely resected, tumor site, tumor size, tumor rupture, nuclear division, kit gene mutation, etc. are also important factors affecting the prognosis. In general, tumor diameter >5cm or 10cm has poor prognosis; tumor rupture also has poor prognosis; nuclear division more than 5/50 HPF or kit gene mutation also indicates poor prognosis. The effect of radiotherapy and chemotherapy as adjuvant treatment is extremely unsatisfactory. Imatinib mesylate, a targeted drug that targets inhibitors of tumor tyrosine kinases, has brought new hope to mesenchymal tumor treatment. Approximately 95% of gastrointestinal mesenchymal tumors contain the enzyme c-kit tyrosinase, which is required for mesenchymal tumor cell growth and survival. Imatinib, an inhibitor of c-kit tyrosinase, blocks c-kit-mediated downward signaling and kills tumor cells. The use of imatinib must be preceded by a test to confirm CD117 positivity. Imatinib has been applied to treat GIST in China since 2001 with considerable results, and randomized trials of preoperative neoadjuvant therapy and postoperative adjuvant therapy are underway. We have achieved satisfactory results in the early diagnosis of gastric mesenchymal tumor using a combination of gastroscopy and endoscopic ultrasonography, and laparoscopic partial gastrectomy with the aid of gastroscopic localization.