Two sore nipples may be related to trauma, inflammation, breast hyperplasia, breast tumor and other diseases. It can be relieved by hot compresses, wearing firm underwear, medication and surgery. 1. Hot compresses: the appearance of two nipple pain may be due to breast hyperplasia or the imbalance of the ratio of estrogen and progesterone. It can be improved by hot compresses and other ways. It can mainly unclog the mammary glands, reduce the discomfort of the human body, and achieve the purpose of treating nipple pain. 2. Wear solid underwear: when women have symptoms of nipple pain, try to wear a solid bra, not only to avoid breast sagging, but also to reduce the pressure on the breasts. Wearing a firm undergarment, especially when playing sports, can protect the health of the breasts. 3. Medication: Many women experience nipple pain. If nipple pain is caused by papillitis, you can take antibiotics such as cefixime. 4. Surgical treatment: if nipple pain may also be breast tumor, such as nipple eczema-like cancer, which is mostly manifested as itching of nipple, areola and its surrounding skin, with red patchy eczema-like appearance, and ulcers can be formed in serious cases. After clear diagnosis, surgical treatment should be chosen under doctor’s guidance, assisted by radiotherapy and chemotherapy. If the two nipple pain persists unrelieved, patients are advised to seek medical attention as soon as possible to clarify the cause of the disease and treat accordingly.