Common causes of age-related knee pain include osteoarthritis of the knee, rheumatoid arthritis, meniscus injuries and so on. Targeted treatment measures should be taken according to the causes, and commonly used treatments include general treatment, physical therapy, medication and surgery. 1. Osteoarthritis of the knee joint: the affected knee joint should be protected, avoiding long-distance running, mountain climbing and bad posture, etc., and the use of a cane or walker should be used to assist in activities. Commonly used drugs such as flurbiprofen gel, non-steroidal anti-inflammatory drugs such as celecoxib, anti-anxiety drugs such as pregabalin. Intra-articular injection of sodium vitrate is also feasible, which can effectively relieve pain, and surgery is needed for severe cases. 2. Rheumatoid arthritis: pay attention to keep warm, avoid moisture and cold. Antibiotics such as benzylpenicillin, non-steroidal anti-inflammatory drugs such as aspirin and glucocorticoids such as dexamethasone can be used. 3. Meniscus injury: need to stop activities, pressure bandage. Early ice packs can be used to reduce swelling. For those with obvious pain and swelling, non-steroidal anti-inflammatory drugs (NSAIDs) can be used as mentioned above, and anti-swelling and analgesic drugs such as tincture of anti-swelling and analgesic can be used, while surgical treatments such as meniscus suturing are needed for serious cases. There may be other causes of senile knee pain, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor targeted treatment.