Oxygen overdose in pregnant women mainly affects fetal blood oxygen supply and has little relation to the eyes; however, overdose of oxygen in preterm infants can lead to retinopathy. In the clinic, when there is fetal distress or developmental delay and other conditions, it will be recommended that pregnant women low-flow oxygen or intermittent oxygen, which can improve the hypoxia of the fetus. However, prolonged oxygen intake by pregnant women will lead to uterine vasoconstriction and reduced placental perfusion, thus affecting the oxygen supply to the fetus, which will also have an effect on the eyes of the fetus, but it is part of the systemic changes caused by hypoxia and is not directly related to oxygen intake. Generally speaking, over-oxygenation in preterm and newborn babies can affect the eyes. Especially in preterm babies, the retinal blood vessels are not fully developed at birth and are sensitive to high oxygen levels, so over-oxygenation may lead to retinopathy. It is recommended that those who find abnormalities should consult a specialist and choose whether or not to take oxygen in strict accordance with the indications for oxygen intake if necessary.