Increased leukocytes and neutrophils are often seen when there is some inflammation or infection, such as lobar pneumonia, purulent tonsillitis, acute gastroenteritis, purulent appendicitis, epidemic hemorrhagic fever, epidemic B encephalitis, typhus, and leptospirosis. In addition, when there is extensive tissue damage and necrosis, the ischemic necrotic tissue can also stimulate leukocytes and neutrophils, which appear significantly elevated, such as extensive burns, surgical trauma, severe trauma, myocardial infarction, and pulmonary infarction, which can lead to significantly high leukocytes and neutrophils. Significantly high leukocytes and neutrophils can also occur in diabetic ketoacidosis and uremic syndrome. Also, in granulocytic leukemia, high white blood cells and neutrophils can occur.