Toothache medication, first of all to determine the cause of toothache to choose the treatment, not all toothache need to use medicine. Usually periodontitis, pulpitis, dental caries and other causes of pain. 1. Periodontitis: Periodontitis will lead to alveolar bone resorption, gum recession, causing the exposure of the tooth root, in the late stage of periodontitis will appear gradually loose teeth, unable to bite hard objects, the whole mouth of multiple teeth swelling and pain phenomenon. Oral antibiotics and painkillers, such as metronidazole, diclofenac sodium or fenbendazole, can be taken, but more importantly, periodontitis requires systematic periodontal treatment. 2. Pulpitis: Pulpitis is mostly caused by trauma and dental caries, causing severe pain to hot and cold stimuli, and is accompanied by spontaneous pain, and even pain at night that makes it impossible to sleep. It cannot be cured by medication, and can only be cured by root canal treatment. 3. Dental caries: dental caries is the most common cause of toothache, if the caries hole is very large, there will be teeth to hot and cold stimulation of transient pain and food blockage pain. When using medication, pay attention to check whether there is a history of allergy to the corresponding drugs, and prohibit the consumption of alcohol during the use of medication. Pay attention to the diet, avoid spicy and stimulating food, so as not to aggravate the inflammation. Filling treatment of carious cavities can be carried out. If the medication can not alleviate the toothache, it is necessary to consult a doctor in a timely manner, under the guidance of the doctor for the cause of the treatment, so as not to delay the condition.