How is diabetic peripheral neuropathy diagnosed? Diabetic peripheral neuropathy has a high incidence, but the early stages of the disease are often asymptomatic, and the longer the course of the disease, the more difficult it is to treat. Therefore, it is important to raise awareness of the disease, strive for early detection and early treatment, reduce the disability rate of patients and improve the quality of life. For all type 2 diabetes at diagnosis, screening for neuropathy should be performed 5 years after the diagnosis of type 1 diabetes, or when manifestations of peripheral neuropathy are present. Qualitative screening includes pinprick testing, light touch, position, temperature, vibration (128 Hz tuning fork), pressure (10 g Semmes-Weinstein single fiber nylon filament), in addition to kinesthetic and ankle reflex testing. Quantitative diagnosis of diabetic peripheral neuropathy includes nerve conduction velocity (NCV); quantitative sensory function measurement (QST); and gastrocnemius nerve biopsy. Generally, by taking a detailed medical history and combining clinical manifestations, physical examination and auxiliary examination results, endocrinologists can make an accurate diagnosis of diabetic peripheral neuropathy. How is diabetic peripheral neuropathy treated? Since the causes and pathogenesis of diabetes and peripheral neuropathy are not fully understood, there is no special treatment yet. In the treatment, corresponding drugs should be chosen for different patients, different conditions and different physiques, and comprehensive treatment such as controlling blood sugar, improving circulation and controlling pain should be taken as the main treatment, supplemented by supportive and symptom-specific treatment. Firstly, blood sugar should be strictly controlled, which is the key and basis for the treatment of diabetic neuropathy, requiring blood sugar to be stabilized at the ideal level. If oral hypoglycemic drugs cannot lower blood sugar to a satisfactory level, insulin can be injected or insulin pump can be used to strictly control blood sugar to prevent diabetic peripheral neuropathy if necessary. Secondly, it includes antiplatelet therapy, relaxation vascular therapy and anticoagulation thrombolytic therapy to improve local microcirculation and promote the repair of damaged nerve tissue. Third, some neurotrophic drugs can be consumed, such as intramuscular injection or oral administration of methyl vitamin B12. Fourth, medications to relieve pain, self-care, etc. In addition, if the patient has hypertension and hyperlipidemia, they should also be controlled together. Finally, don’t forget to quit smoking, limit alcohol, exercise moderately, eat a balanced diet and reduce weight. It should be emphasized that patients need reasonable treatment under the guidance of an endocrinologist.