Children with acute urticaria combined with fever, often in addition to the allergic state, combined with bacterial or viral infections, first of all, it is recommended to improve the blood routine, C-reactive protein and calcitoninogen examination, complete the examination and then combined with the results, to determine whether it is a viral or bacterial infection. If it is a viral infection, you can take anti-viral treatment such as Pudilan Anti-inflammatory Oral Liquid, and if it is a bacterial infection, you need to use cephalosporin antibiotics to fight the infection. Acute urticaria itself is a kind of allergic disease, in the anti-infection treatment, mainly anti-allergy treatment, anti-allergy treatment can be applied to antihistamines, children can use cetirizine syrup, loratadine granules, etc., and topical medication can be used with glycerine lotion. If the disease is more serious, the rash is generalized, and combined with systemic symptoms, such as abdominal pain, chest tightness, etc., it is necessary to control the disease by intravenous injection of methylprednisolone.