Clinically, the so-called typical clinical manifestations of gallbladder perforation usually include abdominal pain, abdominal distension, and even systemic symptoms such as nausea, vomiting, chills, fever, etc., and signs of peritoneal irritation such as compression pain and rebound pain will appear in the right upper abdomen. In current clinical practice, due to the continuous improvement of medical conditions and hygiene standards, the occurrence of gallbladder perforation is minimal, and timely medical attention is usually available when gallbladder pain occurs. Once the gallbladder is perforated, bile from the gallbladder will enter the abdominal cavity in large quantities, resulting in cholestatic peritonitis. First of all, cholestatic peritonitis will cause chemical stimulation of the abdomen, and then the bacteria in it will grow and multiply, thus forming bacterial peritonitis, so when the gallbladder perforation is not treated in time, there will be symptoms of infection and poisoning such as chills, fever, and high fever, and in serious cases, it may even cause infection shock, which may jeopardize the patient’s life.