Dyspnea lying down in uremia may be caused by increased circulatory load due to water and sodium retention, thus inducing heart failure. Uremia is a series of clinical symptoms caused by chronic, progressive and irreversible destruction of renal units due to various renal diseases, resulting in insufficient renal units to expel metabolic wastes and water, and metabolic wastes and water are gathered in the body, resulting in disorders of the water-electrolyte balance, thus causing a series of clinical symptoms. If patients with uremia have difficulty in breathing when lying down, it may be due to more water and sodium retention in the body, resulting in excessive circulatory load, which induces heart failure, exertional dyspnea, cardiac arrhythmia, and in severe cases, cardiac arrest and sudden death, affecting the patient’s physical health. If patients with uremia have difficulty in breathing when lying down, it is recommended to go to a regular hospital in time, and standardize the treatment under the guidance of the doctor.