Patients with significant lower eyelid depressions can have the area filled with hyaluronic acid injections and autologous fat fillers as prescribed by the doctor, as well as through localized massages and a good work routine. 1. Hyaluronic acid injection: Hyaluronic acid is injected as a filler into the sunken area of the lower eyelid to make the sunken area flat. This method is safer, but the maintenance time is shorter, usually lasting only 3~6 months. Therefore, if patients want to maintain the effect, they need to keep injecting. 2. Autologous Liposuction: Autologous liposuction is a minimally invasive liposuction technique that sucks out fat from other parts of the body and delivers it precisely to the depressed area of the lower eyelid to restore the local plumpness. The results of autologous lipofilling last longer than hyaluronic acid. If a patient develops minor lower eyelid depressions due to late nights, no special treatment is usually needed, and the depressions can be improved with periocular massage and a good routine. It is recommended that patients with significant lower eyelid depressions seek prompt medical attention to evaluate their condition and follow their doctor’s instructions for treatment.