Quadruple bactericidal drugs are mainly used to kill H. pylori in clinical practice. Quadruple drugs mainly include two antibiotics plus a proton pump inhibitor, plus a bismuth agent, with antibiotics selected from penicillins, aminoglycosides, quinolones and so on. Proton pump inhibitors are often used omeprazole, rabeprazole, pantoprazole and so on. Bismuth agents are often chosen from colloidal bismuth pectin, bismuth aluminate and so on. Quadruple drugs are mainly designed to kill H. pylori and are taken to reach 10-14 days. In addition, a small number of patients may have drug resistance, so it may be necessary to adjust the type of antibiotics. After the quadruple bactericidal drugs kill H. pylori, we should pay attention to prevent re-infection of H. pylori, we should pay attention to avoid public meals, pay attention to the disinfection of tableware, etc.