Glucocorticoid ointment has anti-inflammatory, anti-allergic, and immunosuppressive effects, and is generally not harmful if used as prescribed. However, if glucocorticoid ointment is used externally for a long time, it may cause dermatitis, hyperpigmentation and hormonal side effects. 1. Dermatitis: If glucocorticoid ointment is applied to the affected area for a long period of time, then it is likely to cause skin irritation, thus triggering dermatitis, at which time the patient’s skin will become unusually sensitive, often with redness, swelling, itching, burning and other problems. 2. Hyperpigmentation: after long-term use of glucocorticoid ointment, the affected area of the skin may have different degrees of hyperpigmentation, mainly black or gray. 3. Hormonal side effects: Because glucocorticoid ointment contains certain glucocorticoids, so after long-term use of large amounts of this ointment, the hormone content in the patient’s body is likely to exceed the standard, which in turn triggers a series of hormonal side effects, such as obesity, osteoporosis, peptic ulcer and so on. Therefore, in the use of glucocorticoid ointment, patients should strictly follow the doctor’s arrangements, according to the condition to standardize the use of medication, do not long-term, large amounts of use. Once the abnormal phenomenon, then we should stop the drug in time, and inform the doctor.