Irbesartan hydrochlorothiazide tablets and nifedipine can not determine which drug is better, it depends on which drug is more suitable for hypertensive patients. Irbesartan hydrochlorothiazide tablets is a compound preparation, including Irbesartan and hydrochlorothiazide two ingredients, Irbesartan’s role is to inhibit angiotensin II receptor, hydrochlorothiazide is a diuretic, the two can increase the effect of lowering blood pressure. Nifedipine tablets are calcium antagonists, mainly through the dilation of peripheral blood vessels to lower blood pressure. Irbesartan hydrochlorothiazide tablets and nifedipine tablets can be used in the treatment of hypertension, different drugs have different characteristics, it is impossible to evaluate which drug is better, according to the characteristics of the patient’s condition to choose the right drug. The adverse reactions of Irbesartan Hydrochlorothiazide include nausea, thirst, fatigue, abdominal pain, diarrhea, muscle aches and pains, etc. It is forbidden for women who are allergic to the drug components, have severe renal impairment, or are breastfeeding during pregnancy. Adverse reactions to nifedipine include flushing, tachycardia, edema of the lower extremities, dry stools, etc. It is contraindicated in patients who are allergic to the components of the drug, severe aortic valve insufficiency and cardiogenic shock. Patients with hypertension should choose antihypertensive drugs under the guidance of a physician and develop a treatment plan according to the patient’s condition.