High pepsin may be due to high pepsinogen 1 and high pepsinogen II. High pepsin does not indicate the extent of the disease and may be caused by physiologic factors. 1. High pepsinogen I: High pepsinogen 1 may be physiologic, for example, irregular eating, intake of stimulating food, overwork of the body, the examination may find high pepsinogen 1, which is a normal physiologic phenomenon. In addition, Helicobacter pylori infection damages the gastric mucosa, resulting in gastritis and gastric ulcers, which may lead to temporary high pepsinogen 1, which can be improved by treatment. 2. High pepsinogen II: High pepsinogen II is considered to be related to chronic inflammation or ulcers in the stomach and duodenum, but it does not indicate that the patient’s condition is serious. If high pepsinogen is caused by physiological factors, no special treatment is needed. If it is suspected to be related to digestive system diseases, it is recommended to go to the gastroenterology department of the hospital for consultation and treatment according to the doctor’s opinion.