Smoking has little effect on the effectiveness of rabies vaccination, but it is still recommended to avoid smoking. Smoking is one of the inoculators’ own factors that have little effect on the effectiveness of rabies vaccination because it does not affect the function of the immune system in a short period of time. Genetic factors, nutritional factors, age factors, and alcohol consumption have a higher effect on the vaccine than smoking. Generally speaking, factors affecting the effectiveness of rabies vaccination include the quality of the vaccine itself, the storage conditions of the vaccine, the route of immunization, and the vaccinee’s own factors. Smoking is not recommended for long-term health, and quitting smoking as soon as possible will help your health.