The nursing care of VSD negative pressure suction pays attention to the following aspects: first, it is necessary to observe whether there is obvious air leakage from the VSD, and if so, it is necessary to use the protective film to apply it in time. Second, the color and character of the drained fluid should be observed during the flushing process, if there is obvious fresh bleeding, timely hemostatic treatment is needed, or the VSD should be disassembled for local trauma hemostasis. Third, it is necessary to prevent water around the VSD, which can easily lead to the adherent mucosa dislodgement, leading to the failure of negative pressure suction, and easy to cause local infection. Fourth, the patient should be allowed to eat nutritious and absorbable food, such as fresh green vegetables, high-quality protein, such as fish, shrimp, leaner beef, etc., which will help the wound recovery. Fifth, let the patient drink water to promote blood circulation and help recovery.