Creatine phosphate isoenzyme (CK-MB) is a type of cardiac enzyme that is elevated for a variety of reasons. Elevated serum CK-MB is mainly used as an important indicator to confirm the presence of myocardial injury, acute myocardial infarction, or other myocardial disorders such as myocarditis. Of course, there are other reasons for CK-MB elevation. Excessive physical activity can also cause CK-MB elevation, such as marathon running or strenuous weight training, and certain malignant tumors can cause false elevation of CK-MB. Hypothyroidism can also lead to an increased percentage of CK-MB, especially when combined with renal failure, which may be due to increased permeability of cardiomyocytes from which the enzyme leaks. Chronic dialysis patients can have pseudo-elevated CK-MB, which may be due to abnormal protein metabolism during chronic dialysis. Pulmonary embolism can lead to elevated CK-MB, which is attributed to the fact that pulmonary embolism can lead to increased right ventricular loading, increased right ventricular oxygen demand and decreased perfusion, leading to myocardial hypoxia and causing elevations in cardiac enzymes and other myocardial markers.Beta agonist therapy for asthma can lead to a transient elevation of CK-MB, which is probably related to the effects of adrenergic stimulation on the myocardium. Although there are many reasons for elevated creatine phosphate isoenzyme, once high creatine phosphate isoenzyme is observed clinically, the first thing you should do is to go ahead and rule out and confirm the presence of cardiac disease.