Closure injections will be painless for 1 to 2 hours if the medication injected contains anesthesia. In case of tendinitis, it will be painless in about 6 hours. In case of inflammation of deep ligaments, it will be painless after 12 to 24 hours. 1. Containing anesthesia ingredients: If the medication injected contains anesthesia ingredients, the pain may disappear a little faster, in about one to two hours. 2. Tendinitis: If it is some superficial aseptic inflammation, such as tenosynovitis, the pain symptom is usually relieved in about six hours after injection. 3. Inflammation of deep ligaments: In case of inflammation of deep ligaments, such as inflammation of the medial fibular ligament of the knee joint, periarthritis, etc., the effect of the medicine may be exerted in 12 to 24 hours. After the closed injection must pay attention to keep the skin dry, do not scratch, avoid repeatedly pulling the closed area, so as not to cause the swelling of the aggravation and thus delay the pain relief.