Red, swollen and whitehead acne can be treated with topical medications with anti-infective effects such as fusidic acid cream, azelaic acid cream and benzoyl peroxide. 1. Fusidic acid cream: for all kinds of bacterial skin infections, mainly used for skin infections caused by gram-positive cocci, sensitive to Propionibacterium acnes, antibacterial effect is good, low drug resistance. 2. Azelaic acid cream: it is suitable for the local treatment of mild and moderate inflammatory acne vulgaris, it has antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis, because it does not belong to the antibiotics, so it does not produce drug resistance in general. 3. Benzoyl peroxide: It is an oxidizing agent that produces bactericidal effect through oxidation reaction, so it does not produce drug resistance, but it can lead to dry and flaky skin. When redness, swelling, whiteheads and inflammation are obvious, it is recommended to take oral minocycline, doxycycline and other drugs. The above medications should be used under the guidance of a physician and should not be used on their own.