A 6mm ground-glass nodule in the lung can be combined with other clinical data to determine the benign or malignant nature; benign nodules can be followed up regularly, and surgical resection is feasible when malignancy is suspected. Ground-glass nodules in the lungs include pure ground-glass nodules and mixed ground-glass nodules, which are categorized into benign and malignant nodules. Benign nodules usually have uniform density, well-defined margins and no internal lobulation. When a nodule with a diameter of 6 mm is considered benign or when the nature of the nodule is uncertain, imaging follow-up can be performed within 3 months, and then annually if there is no change in the shape or size of the nodule. When a 6mm nodule is suspected to be malignant, such as irregular nodule margins, lobular sign, burr sign, vascular trophoblastic vessels and other imaging manifestations, biopsy and puncture or surgical resection is feasible to clarify the nature of the nodule. 6mm pulmonary ground-glass nodules, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor, reasonable and standardized treatment.