Holding urine in the bladder can cause a range of urological disorders, but is part of the process of holding urine in large quantities for a long period of time, and an occasional holding of urine does not significantly affect organic damage. The following diseases may occur: 1. Bladder trabecular hyperplasia, when holding urine for a long time in large quantities, the bladder trabeculae will compensate for the hyperplasia. It is also the same as the human limb if it is weight-bearing for a long time, the muscles will become thicker. So a long time of comparison, the muscles within the bladder will become thicker, over time it is easy to cause fatigue of the bladder forcing muscle, and cause a lack of power of the bladder forcing muscle. 2, holding urine for a long time can lead to hydronephrosis, after a certain amount of urine is stored in the bladder, urine does not reflux to the kidneys, but when a long time of holding urine in large quantities over a certain pressure, urine will flow from the bladder into the ureter to However, when a large amount of urine is held for a long time beyond a certain pressure, urine will flow from the bladder into the ureter to the kidneys, and over time, a double hydronephrosis will form. When the double hydronephrosis occurs, if there is still a long time to hold a lot of urine cause, may gradually appear the performance of renal insufficiency. 3, a long time to hold a lot of urine will cause the probability of urinary tract infections to increase, because the urine stored in the bladder for a long time, over time it is easy to occur bacterial breeding or deterioration, over time it is easy to cause the probability of infection significantly increased.