Isosorbide mononitrate and isosorbide nitrate generally can not be taken at the same time, because both types of drugs belong to the nitric acid class of drugs, pharmacological effects are similar, if overdose may affect the health of the body, is not conducive to the recovery of the disease. Isosorbide mononitrate is a vasodilator drug, can treat coronary heart disease, angina, myocardial infarction and other diseases. Isosorbide nitrate also belongs to a kind of vasodilator drug, which can be used for the long-term treatment of coronary heart disease, the prevention of angina pectoris, and the treatment of myocardial infarction at present. Isosorbide mononitrate and isosorbide nitrate are similar in their pharmacologic effects and may have additive effects and increased side effects. Therefore, isosorbide mononitrate and isosorbide nitrate are generally not recommended to be taken at the same time. So as not to aggravate palpitations, vertigo, nausea, dizziness, syncope and other adverse reactions, damage to health. It should be noted that acute circulatory failure, severe hypotension, severe anemia, allergies, should be cautious or contraindicated to take the drug.