High white blood cells in cerebrospinal fluid found on examination may be caused by factors such as encephalitis and meningitis, and the cause should be identified by seeking medical treatment promptly. 1. Encephalitis: caused by infection with pathogenic factors such as bacteria, molds, spirochetes rickettsiae, parasites, etc. It may also be caused by autoimmune diseases, resulting in a significant increase in white blood cells in cerebrospinal fluid. 2. Meningitis: Inflammation of the cerebrospinal membrane caused by purulent bacterial infections (e.g. pneumococcus, meningococcus, etc.) will show symptoms of elevated leukocytes in the cerebrospinal fluid, and thus high leukocytes in the cerebrospinal fluid can occur. If high cerebrospinal fluid white blood cells are found on examination, you should seek medical treatment in time, and carry out targeted treatment under the guidance of your doctor to avoid delaying your condition.