Patients with nephrotic syndrome are able to carry out normal work, nephrotic syndrome is a relatively common type of nephrology disease, clinical manifestations of edema, large amount of proteinuria, hypoproteinemia and hyperlipidemia, causing nephrotic syndrome is the most common type of pathology is the microscopic lesions and membranous nephropathy, the less common type is the membranoproliferative glomerulonephritis and segmental sclerosing glomerulonephritis. For nephrotic syndrome, the first step is to do a renal puncture to clarify the specific type of pathology. Hormone or immunosuppressant treatment is chosen according to the pathologic type, for example, the commonly used treatment plan for microscopic lesions is adequate hormone. Membranous nephropathy is commonly treated with hormone combined with cyclophosphamide or small-dose hormone combined with tacrolimus. Nephrotic syndrome can often be clinically cured after drug treatment, and there is no problem to go to work at this time, but we should avoid overwork as well as prevent cold and flu to avoid triggering the recurrence of the disease again.