Pathologic diagnosis of colon polyps after surgery mucosa with visible foam cells suggests benign, accompanied by the possibility of inflammatory reaction. Immunohistochemistry can be done for further clarification. Pathologic diagnosis should also have a description of cell morphology and structure. If the morphology and structure of the cells are normal, it is mostly benign hyperplasia. If there is heterogeneous hyperplasia, it indicates the possibility of malignant transformation, and the larger the heterogeneity, the greater the possibility of cancer. Colonic polyp refers to the growth of superfluous organisms on the surface of colonic mucosa. Including adenomatous polyps, hyperplastic polyps, misshapen tumors and inflammatory polyps, polyps have a certain degree of malignancy, especially adenomatous polyps. Surgery should be considered if there are colonic polyps, and inflammatory polyps should be treated according to the type of inflammation. Such as ulcerative colitis, Crohn’s disease. Colon polyps after surgery pathology diagnosis mucosa has visible foam cells, it is recommended to consult with the specific pathology report to analyze the condition.