Low blood pressure due to coronary artery disease can be seen in two cases, the patient’s cardiac output is reduced or the diastolic effect of antihypertensive drugs is too large, according to the above reasons need to digoxin, cediran cardiac therapy or adjust the dose or type of antihypertensive drugs. Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, which refers to heart disease caused by atherosclerosis of coronary arteries resulting in narrowing or occlusion of blood vessels, leading to myocardial ischemia or necrosis. First of all, coronary artery disease will appear in severe cases of heart failure, due to the reduction of cardiac output triggered by low blood pressure, at this time should be given to positive inotropic drugs such as digoxin, cediran to strengthen the heart treatment. Secondly, if patients with coronary artery disease apply antihypertensive drugs with excessive vasodilator effect, such as nitrate (isosorbide mononitrate, isosorbide dinitrate), calcium channel blocker (verapamil, nifedipine) will also appear hypotension, according to the situation of the blood pressure can be gradually cut down or replace the drug, if necessary, need to be static high-dose dobutamine to raise the blood pressure. If patients with coronary artery disease experience hypotension, it is not recommended to adjust the medication by oneself, but should consult a specialist and adjust the treatment according to the doctor’s instructions to avoid serious consequences.