Multiple negative breath tests but positive gastroscopic biopsies may be false negatives caused by medications or disease effects, and the results of the gastroscopic biopsy should be used as the basis for treatment against H. pylori infection.
The breath test determines the presence or absence of H. pylori infection by examining the concentration of urease produced by H. pylori in the stomach. Fasting is required before the test, and no oral proton pump inhibitors should be taken within 2 weeks and no oral antibiotics should be taken within 4 weeks prior to the test, as this may lead to false-negative results.
Gastroscopic biopsy is a pathologic examination of diseased gastric mucosal tissue under gastroscope, which is more objective, and if the result is positive, it can be concluded that the infection is present. It is necessary to take anti-Helicobacter pylori treatment, can choose bismuth such as bismuth potassium citrate, bismuth pectin, etc., proton pump inhibitors such as omeprazole, etc., two antibiotics such as metronidazole, amoxicillin, clarithromycin, etc. Quadruple therapy.
It is recommended that patients with positive gastroscopy biopsy go to regular hospitals in time, and standardize treatment under the guidance of doctors, so as not to delay the condition or lead to adverse reactions.