”You reap what you sow.” Natural conception through pharmacological treatment remains the quest of many doctors and patients. In terms of efficacy, medication for infertility can be divided into three categories: specific, semi-specific, and non-specific treatments. When the cause is clearly diagnosed and therapeutic measures are available to address the cause, the treatment will be more satisfactory, which is called “specific treatment”. Unfortunately, among the many causes of male infertility listed in the “Male Disease Treatment Guide – Male Infertility Treatment Guide”, only infertility due to “hypogonadism” is stated as “gonadotropin treatment – treatable”. However, 60-75% of patients have idiopathic oligospermia, hypospermia and/or aberrant spermatozoa, for which empirical treatment, also known as “non-specific treatment”, is often indicated. The empirical therapies recommended in the treatment guidelines are divided into hormonal and non-hormonal categories. For example, there are five hormonal drugs listed, but four of them are written as “ineffective and not recommended”, while the remaining one is written as “possibly effective”. As for the seven non-hormonal drugs, three were written “ineffective”, two were written “efficacy not confirmed”, and two were written “partially effective”, but “Only for clinical trials”. This is equivalent to the fact that none of the 7 non-hormonal drugs are really effective. As for some genetic factors or genetic defects caused by infertility, primary spermatogenic dysfunction and obstructive azoospermia, lifestyle changes or medication are unlikely to change the status quo of infertility, so there is no need to consider medication at all, and at this point, assisted reproductive technology should be considered. Assisted reproduction The development of assisted reproduction technology has provided a new world for the treatment of male infertility, and IVF born from artificial fertilization is divided into the first and second generation. The first generation of IVF (in vitro fertilization-embryo transfer, IVF-ET) is mainly aimed at treating female infertility; while the second generation of IVF (single sperm oocyte injection, ICSI) is only aimed at treating male infertility, which can be considered a milestone advancement in male infertility treatment. Single sperm oocyte injection (ICSI), the definitive treatment for infertility, is the most laborious, invasive, and expensive modality, and ICSI treatment may pass on the risk of chromosomal, genetic, and other genetic defects to the offspring; therefore, couples undergoing ICSI treatment should have a chromosome analysis. However, before considering assisted reproductive technology, there is one issue that should be clear. Some reports show that the pregnancy rate for second-generation IVF after 3 cycles of treatment is about 40%, while the rate of holding a baby is about 20%. This is considered low in the eyes of the patient. But the opposite of this “low” success rate is the high cost. A cycle of IVF can cost as little as 20,000 to 30,000 RMB. In the meantime, if the response to conception is not good and you need to conceive again, the cost may rise to 40,000 to 50,000 RMB. It is a fixed thinking that “the patient goes to the doctor for treatment of illness”. However, according to a survey in Jiangsu, alcoholism, smoking, cola, coffee and staying up late can affect sperm quality. It is worth mentioning that the radiation from computer rooms and cell phones has a greater impact on sperm malformation, often more than 1 month 2 months of pregnancy, but not more than six months of fetal development stopped – abortion. Therefore, in daily life, in addition to quitting smoking and drinking, it is especially necessary to properly reduce the contact time of computers, cell phones and other electrical appliances, get enough sleep, keep a good state of mind and go for a walk with your wife. In addition to lifestyle habits, patients should also understand some basic knowledge of fertility, such as: women only have a chance to get pregnant when they are ovulating, and couples should increase the number of sexual intercourse appropriately during ovulation to be more likely to conceive a child. This is especially important for some people whose semen quality is not so good. The Chinese medicine is also known as “male infertility”, “childlessness”, “no heir”, “fecundity” and so on. The “Golden Knot” has a record that “the man’s pulse is weak and astringent, for childlessness, the essence is cold”. The “Secret Seed Golden Dan” by Ye Tianshi also refers to male infertility as “man’s difficult heir”. Based on many years of clinical experience and repeated practice, we have developed our own unique system of diagnosis and treatment. We believe that male infertility is mainly due to kidney deficiency, and is related to the liver and spleen, as well as damp heat, liver depression, blood stasis, etc. The treatment advocates strengthening the spleen and benefiting the kidneys as the fundamental method, and supplementing the kidneys is based on the theory of mutual root of yin and yang. The good tonic for yin must seek yin in yang, so that yin can be raised by yang and the source of spring is inexhaustible. The treatment needs to seek yang in yin and yin in yang. The patient has been ill for a long time, the pressure from the family patients more or less will have psychological problems, Chinese medicine called liver depression, “see the liver disease, know that the liver transmits the spleen, when the first real spleen”, so should dredge the liver to strengthen the spleen, but a single dredge the liver will affect the vitality of sperm, should gradually turn to strengthen the spleen to benefit the kidney method as the main treatment. Therefore, male infertility caused by low sperm quality should start with regulating the spleen and kidney, and clinically, deficiency of the spleen and kidney and deficiency of qi and blood are also common. Therefore, we established “deficiency of both spleen and kidney” as the basic pathology of modern male infertility, and used this theory as a guide to form the Chinese herbal formula Sequel Seed Formula for the treatment of male infertility with few and weak spermatozoa. Clinical observation shows that the formula has good efficacy in the treatment of oligozoospermia and can significantly improve the sperm vitality and viability of patients. Our preliminary study found that the formula can improve the antioxidant effect and energy metabolism of the epididymis and testes, maintain the stability of the microenvironment for sperm development and maturation, and improve the patient’s own fertility. In our clinical practice, according to the specific situation, for example, if hypospermia is combined with prostatitis and seminal fluid non-liquefaction, we mostly use Sequel Seed Formula, which has the function of strengthening the spleen, tonifying the kidney and relieving dampness; if poor sexual function or no special symptoms, we use Sequel Seed Formula II (Yangzhen Tang); if combined with varicocele, low sperm count (low sperm density, low sperm concentration and oligospermia), we use Sequel Seed Formula III (Dahuang V Worm Pill). Pill).