Thyroid nodules with pressure sensation should be surgically removed to relieve the pressure, and can be treated with drugs such as levothyroxine sodium tablets after surgery. If combined with hyperthyroidism, anti-thyroid drugs can be taken to treat. Most patients with thyroid nodules do not have obvious clinical symptoms, which are usually detected during physical examination or neck ultrasound or neck CT; when it causes symptoms of pressure sensation, coughing, shortness of breath and other discomforts may occur, and medication is not recommended, and surgical treatment should be carried out. Since the thyroid gland may be damaged during surgery, levothyroxine can be taken as replacement therapy after surgery. If combined with hyperthyroidism, anti-thyroid medication can be taken. When symptoms of thyroid nodule pressure appear, it is recommended to go to the hospital in time for early standardized treatment.