The flesh at the edge of the nail cap of the big toe is clinically known as the nail bed. Nail bed pain when pressed may be caused by physiological reasons such as long-term wear and tear, inappropriate shoes, etc., or it may be caused by pathologic factors such as infection or trauma. 1. Physiological reasons: If you walk for a long time or the shoes do not fit properly, the big toe of the foot and the shoes can be rubbed and squeezed, resulting in aseptic inflammation of the local soft tissues of the nail bed, and the nail bed can be painful when it is pressed, which can be gradually relieved by taking proper rests and replacing the shoes with comfortable ones. 2. Infection: various reasons lead to the nail bed by pathogenic bacteria invasion, will cause nail bed infection, such as acute onychomycosis, nail bed abscess, etc., can be manifested as nail bed pressure pain. 3. Trauma: due to smashing, extrusion injury and other factors, can lead to soft tissue damage around the toes, or even toe bone fracture, there will be symptoms of pain when pressing the nail bed. If the symptoms of pain in the nail bed of the toe are not relieved, or accompanied by other symptoms, you should go to the hospital in time, and give targeted treatment after clarifying the cause.