Pain is an important signal that the human body is ill and it reminds people that they should go to the hospital promptly, which is the beneficial side of pain for the human body. However, in the vast majority of cases, pain can bring serious harm to the body and even cause catastrophic consequences. Mild pain can cause mental suffering, affect diet and living, and lead to a decrease in quality of life; severe pain will cause dysfunction of various systems, low immunity and induce various complications, and even lead to painful disability or affect the life of the patient. In reality, it is not uncommon for patients to suffer from chronic pain for a long period of time, resulting in a variety of illnesses and even lightness of life. Therefore, it is a very old-fashioned and harmful misconception that pain is not a ‘disease’ and does not need to be treated specifically. Timely diagnosis and treatment of pain and effective pain control is an important part of life’s health. With the advancement of medicine, pain research and treatment has entered a specialized stage of development. Modern medical research has shown that many chronic pains are diseases in themselves, not just a symptom. Pain often coexists with other diseases or can appear alone, and pain problems need to be treated with a professional attitude and managed with professional means. In the past, the piecemeal and reactive pain management model of different clinical specialties was far from adequate to meet the clinical needs. In this context, a new discipline, pain medicine, was born and has been developing rapidly. Under the guidance of modern pain theory, the Department of Pain Medicine conducts a new mode of comprehensive analysis and treatment for painful diseases and difficult pain problems encountered in clinical medicine. It has enabled many painful diseases that are difficult to control to be treated perfectly. For common chronic pain diseases such as head and facial pain, cervical spondylosis, frozen shoulder, intervertebral disc lesions, lumbar back and lower limb pain, we use nerve block, minimally invasive radiofrequency thermocoagulation, nerve stimulation, drugs and other comprehensive therapies, which can effectively improve the local blood circulation disorder of pain, remove inflammatory metabolites and interrupt the vicious cycle of pain, so as to achieve the effect of “treating both the symptoms and the root cause “The analgesic effect can be achieved by improving the local blood circulation barrier, removing the inflammatory metabolites and interrupting the pain cycle. For herpes zoster and its sequelae, trigeminal neuralgia, sciatica, phantom limb pain, burning pain and other intractable neuronal pain, we have achieved satisfactory pain treatment effects by blocking nociceptive conduction pathways, improving nerve nutritional status and adjusting nerve conduction function through the application of specific nerve block techniques and nerve frequency (thermal) electrical modulation stimulation. For cancer pain, the latest cancer pain control methods are applied to combine the patient’s physical condition and pain site, and the nerves conducting pain are highly selectively blocked or destroyed, so that more perfect medium- and long-term analgesic effects can be achieved in one treatment. The advantages of this method in treating cancer pain are that it can minimize the common side effects in traditional cancer pain treatment, and has a positive effect on relieving patients’ adverse emotions such as fear, anxiety and depression caused by cancer pain, enhancing appetite, improving sleep and improving their quality of life. In addition, applying the unique means of pain treatment to certain non-painful diseases such as chronic rhinitis, sudden deafness, retinopathy, insomnia, persistent erratic, dysmenorrhea, chronic fatigue syndrome, etc., can also achieve more satisfactory results.