RET gene rearrangement negative has both good and bad sides. 1. RET gene is a proto-oncogene, and there is a correlation between the mutation of this gene and the occurrence of some malignant tumors. Therefore, a positive rearrangement of this gene may indicate that the tested person has an increased risk of developing cancer, while for patients with tumors, it suggests that the tumor has nothing to do with this gene, and will not lead to a poor prognosis due to this gene. This is a good thing from this aspect. 2. Negative RET gene rearrangement often indicates that the patient may not be sensitive to certain targeted drugs against RET gene, and it is not recommended to choose this kind of targeted drug treatment, such as Platinib. It is not a good thing for tumor patients to have one less targeted drug to choose from in this aspect. It is recommended that patients choose appropriate treatments under the guidance of doctors and actively treat them to prolong survival.