At the age of 42, no menstruation, and then again at the age of 48 is not normal, may be the phenomenon of atrophic vaginitis, endometrial cancer. 1. Atrophic vaginitis: Atrophic vaginitis is mainly caused by the decline of ovarian function, the decrease of estrogen level, the atrophy of vaginal wall, the thinning of mucous membrane, and the decrease of vaginal resistance. Infected patients, the secretion is pus and blood, and the abnormal blood secretion makes patients think that menopause occurs at the age of 42 and comes back at the age of 48. 3. Endometrial cancer: endometrial cancer is a kind of cancer that occurs in the endometrium. In the early stage of the disease, it is mainly manifested by abnormal bleeding and vaginal secretion. The amount of bleeding in the early stage of endometrial cancer is usually small and mainly manifested as irregular bleeding. There are many reasons why you don’t have menstruation at the age of 42 and then come back at the age of 48, including vaginitis, cervical cancer, cervical polyps and so on. If bleeding occurs, it is recommended to consult a doctor in time, complete the relevant examination, clarify the cause of the disease under the guidance of a professional doctor, and actively treat it.