Finding out high gastrin should adjust the diet or use azithromycin, amoxicillin, omeprazole and other drugs to treat, some people need to use surgical resection treatment. Some people with high gastrin are physiological increase, the body will not be accompanied by other symptoms, should regulate the dietary problems, diet to avoid eating high fat, high cholesterol food, but should be light diet to help improve the physiological increase in gastrin. Some are caused by diseases such as duodenal ulcer and atrophic gastritis, which are strongly associated with Helicobacter pylori infection and therefore need to be treated with a combination of antibiotic drugs. Azithromycin is a broad-spectrum antibiotic that can kill bacteria in the stomach and has fewer side effects. Azithromycin can be combined with amoxicillin, and the combination of the two antibiotics has a better effect on killing H. pylori. Omeprazole is a drug that inhibits the secretion of gastric acid, which can change the living environment of H. pylori and improve the effect of treatment. High gastrin is also directly related to gastrinoma disease, which can be treated by surgical resection. Because gastrinoma has a certain possibility of malignancy, some people should also combine radiation and chemotherapy after surgery.