Bitter and sticky mouth may be related to gastroesophageal reflux disease (GERD), cholecystitis, diabetes and other diseases. 1. Gastroesophageal Reflux Disease (GERD): GERD patients may experience relaxation of the lower esophageal sphincter, slowing of gastric peristalsis, etc. Gastric juices may reflux into the esophagus, mouth, etc., resulting in clinical symptoms such as a bitter and sticky taste in the mouth. 2. Cholecystitis: Gallbladder stones, bacteria and other pathogenic microbial infections may lead to cholecystitis. Patients with cholecystitis have abnormal bile secretion, which affects the normal digestion and absorption functions and makes them prone to bitter and sticky mouth. 3. Diabetes: The sugar metabolism in diabetic patients is abnormal. Prolonged high blood sugar in the state, will also affect the normal digestion and absorption function, resulting in the emergence of bitter mouth sticky situation. There may be other clinical reasons that can lead to bitter and sticky mouth. It is recommended to go to the hospital as soon as possible, and cooperate with the doctor to improve the relevant examination to clarify the cause of the disease.